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Ecstasy can also be dangerous to overall health and, on rare occasions, lethal.
Weekly use of MDMA over a prolonged period may actually cause serotonin receptors to retreat into the dendrite of serotonin nerve cells. Depression and deficits in memory have been shown to occur more frequently in long-term MDMA users.
The rate of heroin lifetime heroin use is higher among those in prison (23.4 percent for State and 17.9 percent for Federal).
Cocaine hydrochloride, the form in which cocaine is snorted or injected is often "cut," or mixed, with things that look like it. The final product can be from 1% to 95% pure. Common additives are sugars, such as mannitol, lactose, or glucose, or even sugar substitutes, and local anesthetics such as tetracaine, procaine, and lidocaine. Quinine, talc, and cornstarch have also been used. Some consumers may unknowingly purchase a supply without any cocaine, but just a cocaine substitute such as caffeine, amphetamine, PCP, procaine, and lidocaine.

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